Laser Science and Technology
Sara Fadhil Abbas; Adawiya J. Haider; Sharafaldin Al-Musawi; Bakr Ahmed Taha
Abstract
In this study, we synthesized magnesium oxide (MgO) nano flakes (NFs) through pulsed laser ablation of magnesium ribbons, investigating their potent antibacterial properties for potential biomedical applications. Thorough characterization utilizing advanced analytical techniques verified the phase purity ...
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In this study, we synthesized magnesium oxide (MgO) nano flakes (NFs) through pulsed laser ablation of magnesium ribbons, investigating their potent antibacterial properties for potential biomedical applications. Thorough characterization utilizing advanced analytical techniques verified the phase purity and functionality of the fabricated MgO NFs. Results revealed a distinctive flake-like structure with an average diameter of 100-400 nm and a slender wall thickness of 24 nm. The efficiency of the laser ablation method was validated by EDX imaging, showing high purity in the MgO sample. XRD analysis further confirmed the polycrystalline nature of MgO NFs, with dominant peaks at 2θ values of 38.86°, 59.46°, 62.83°, and 73.87° corresponding to (111), (110), (220), and (311) diffractions, respectively. UV-visible spectroscopy exhibited a broad absorption peak, and Tauc's formula yielded an energy band gap of 5.8 eV. FTIR spectroscopy detected Mg–O–Mg bending vibration, O−H stretching vibration, O=C=O stretching, and O−H bending vibration. Optimized MgO-NFs demonstrated remarkable antibacterial efficacy against both gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) bacteria. Maximum antibacterial activity was observed at a high MgO NFs concentration (200 µg/mL), resulting in 15 mm ±0.5 mm and 16 mm ±0.5 mm inhibition zones for E. coli and S. aureus, respectively. The minimum inhibitory concentration (MIC) for both pathogens was determined to be 25 µg/mL, emphasizing the promising antimicrobial potential of the MgO NFs.
Nanotechnology
Rusul Al-Obaidy; Adawiya J. Haider; Sharafaldin Al-Musawi; Norhana Arsad
Abstract
In this work, the development of nanosystems by Pulsed Laser Ablation in Liquid (PLAIL) is of considerable importance to expand their biomedical applications, such as drug delivery. In the present study, we focus on the conditions of the preparation Nd: YAG laser wavelength 266 nm and two different laser ...
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In this work, the development of nanosystems by Pulsed Laser Ablation in Liquid (PLAIL) is of considerable importance to expand their biomedical applications, such as drug delivery. In the present study, we focus on the conditions of the preparation Nd: YAG laser wavelength 266 nm and two different laser fluency (10,28) J/cm2 to control the concentration and size stability of superparamagnetic iron oxide nanoparticles (SPION) prepared by PLAIL. The characteristics of SPION are investigated by energy-dispersive X-ray spectroscopy (EDX) spectra which showed strong peaks of Fe and O. Magnetic characteristics of iron oxide nanoparticles indicated superparamagnetic properties of SPION and suitable physical stability. Optical and chemical properties of SPION were investigated using UV-visible spectra (UV) and infrared Fourier transformed spectroscopy (FTIR). Scanning electron microscopy (SEM) was used to obtain surface morphological studies of SPION. Results showed that SPION is the only cubic shape, the peak absorption shifted toward short wavelengths with optimum concentration to the SPION in double deionized water (DDW) and in Acetone (0.75,0.33) mg/ml respectively, at high laser fluence 28 J/cm2, and this enhancement of value is due to particle size and color resultant in a solution. Eventually, this product has the optimal SPION specialty ratio of SPION in the DDW solution at 53.89%, and the size is very suitable for drug delivery applications.
Nanotechnology
Anwar Sabri Jawad; Qasim N. Thewaini; Sharafaldin Al-Musawi
Abstract
Aluminum oxide, often known as Al2O3, is a chemical compound of aluminum and oxygen with the formula Al2O3. It's the most common of many aluminum oxides, known as aluminum (III) oxide. The study investigates the cytotoxicity and antibacterial effects of Aluminum oxide nanoparticles (Al2O3-NPs) in different ...
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Aluminum oxide, often known as Al2O3, is a chemical compound of aluminum and oxygen with the formula Al2O3. It's the most common of many aluminum oxides, known as aluminum (III) oxide. The study investigates the cytotoxicity and antibacterial effects of Aluminum oxide nanoparticles (Al2O3-NPs) in different cells and bacteria. Different characterization methods such as dynamic light scattering (DLS), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) have been used to evaluate morphologies and physicochemical properties of Al2O3-NPs. MTT technique is used for determining NPs cytotoxicity. The size distribution of Al2O3-NPs was 68 ± 12 nm in diameter, while the zeta potential was (-36 ± 10 mV). There is no toxicity by using the MTT assay, as well as showed antibacterial activity was formed at 200 µg/mL, while the higher antibacterial activity was occurring at (18 ± 0.2) and (17 ± 0.1) for Proteus Vulgaris and Streptococcus pyogenes, respectively. The findings confirmed that the Al2O3-NPs have small dimensions, high stability, and increased antibacterial activity.
Nanotechnology
Maha A Al-Kinani; Adawiya Haider; Sharafaldin Al-Musawi
Abstract
Drug delivery using nanocarriers is recommended to decrease the drug amount. To improve the different therapeutic characteristics of curcumin (CU) such as solubility, bioavailability, maintenance endorsement, and make it a promising, successful antitumor drug used for prostate cancer treatment. It was ...
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Drug delivery using nanocarriers is recommended to decrease the drug amount. To improve the different therapeutic characteristics of curcumin (CU) such as solubility, bioavailability, maintenance endorsement, and make it a promising, successful antitumor drug used for prostate cancer treatment. It was introduced to folate decorated chitosan (CS) coated Fe@Au NPs (FA-CU-CS-Fe@Au NPs). Fe@Au nanoparticle contains magnetic Fe NP’s core with a fine layer of Au NP’s synthesized using the method Pulsed, Laser, Ablation in Liquid (PLAL). These Fe@Au NP’s characterized by UV-Visible Spectrophotometer, High-Resolution, Transmission Electron Microscopy, (HRTEM), and Field Emission Scanning, Electron, Microscopy (FESEM). The smallest nanosize and the best result was obtained at different laser wavelength (532, 1064) nm. The mean size gained of Fe@Au NPs were (67.65, 77.88) nm. Obtained results exhibited that the laser wavelength plays a key role in the size, and dispersity of Fe@Au NPs. CU loaded FA-CS-Fe@Au NPs MTT assay on human prostate cancer cell line (PC3) proved that CU cytotoxicity can improve when they are loaded on (FA-CS-Fe@Au NPs) when comparing it with free CU.
