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Abstract

This work involved synthesizing Au@Ag@Au core double-shelled structures in deionized water (DW) using various laser energies (300, 500, and 700 mJ). These compounds served as antimicrobial agents against two bacterial types: Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Acinetobacter baumannii (A. baumannii). The findings showed that bactericidal efficacy increased with higher laser energy. During production, a pulsed Nd-YAG laser synthesized Au@Ag@Au core-double-shell nanoparticles (NPs) in a 5 mL DW solution. The laser generated 250 pulses at energy levels of 300, 500, and 700 mJ. The device operated at a wavelength of 1064 nm. XRD analysis confirmed the crystal structure, revealing crystallite sizes of 29.267 nm, 27.792 nm, and 24.78 nm for the respective energies. TEM confirmed spherical particle diameters of 28 nm, 24 nm, and 13 nm. Surface plasmon resonance (SPR) studies indicated a blue shift in the plasmon peak amplitude with increased energy, implying reduced particle sizes. Tauc's analysis produced energy gaps of 2.08, 2.12, and 2.13 eV for each specimen. Zeta potential studies indicated stability levels of -14.6 mV, -40.4 mV, and -44.6 mV for these particles. The Au@Ag@Au NPs demonstrated efficacy against S. aureus and A. baumannii, highlighting their promise as antibacterial agents, with molecular docking studies suggesting enhanced stability and adhesion to A. baumannii.

DOI

10.53293/2788-6867.1179

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