Chemistry
Enass J. Waheed; Ali M. A. Al-Khazraji; Awf A. R. Ahmed
Abstract
Mannich base is a versatile compound that can be easily modified to introduce different functional groups, allowing for the creation diverse selection of items with varying features. Additionally, the Mannich reaction is a valuable tool in organic synthesis, due to the fact it provides an effortless ...
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Mannich base is a versatile compound that can be easily modified to introduce different functional groups, allowing for the creation diverse selection of items with varying features. Additionally, the Mannich reaction is a valuable tool in organic synthesis, due to the fact it provides an effortless and efficient approach for synthesizing C-N bonds. Overall, The Mannich base and even its derivatives are essential in many aspects of chemistry and its complexes are in the pharmaceutical industry. Studies have revealed that it shows good anti-cancer, anti-mycobacterial, remarkable anti-HIV, anti-tubercular, anti-convulsant, anti-fungal, antiviral, antitumor, cytotoxic activities and in industrial applications such as in the creation of polymers, surface activity agents, deter gents and resins. The presence of the basic Mannich sidechain has shown marked antimalarial, anti - inflammatory, analgesic and anti - microbial activities. These compounds have also been shown to inhibit corrosion, as well as antioxidant and reducing agents. This review article shows the definition, importance and different applications of Mannich base ligands with transitional metal. These complexes exhibit potent anti-microbial, antiviral, and anti-cancer activities, showcasing their potential in pharmaceutical research and drug development. Moreover, the luminescent properties of Mannich base metal complexes have been harnessed for applications in optoelectronics and sensing. Their tunable emission profiles make them suitable candidates for various sensing platforms and light-emitting devices Mannich base metal complexes.
Biotechnology
Zahraa A. Kadhim; Ghassan M. Sulaiman; Ahmed M. Al-Shammari; Hamdoon A. Mohammed; Salman A. A. Mohammed
Abstract
Glioblastoma multiforme (GBM) is one of the most life-threatening types of cancer that is difficult to treat. The search for effective yet safe therapy is progressing and non-conventional therapies such as using viruses as a smart and selective agent against cancer are promising. The aim of the study ...
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Glioblastoma multiforme (GBM) is one of the most life-threatening types of cancer that is difficult to treat. The search for effective yet safe therapy is progressing and non-conventional therapies such as using viruses as a smart and selective agent against cancer are promising. The aim of the study was the presence of a reliable method to use Newcastle disease virus (NDV) as an oncolytic agent against GBM, which attempted to propagate the NDV in laboratory experiments. Ahmed Majeed Hamza Al-Shammari-1 (AMHA1) attenuated strain of NDV was propagated in chicken embryos. The virus's tittered in Vero-slamed cells to determine the infective dose. MTT cell viability assay was used to investigate the killing effects of NDV on Ahmed-Majeed-Glioblastoma-Multiforme-2005 (AMGM5) human glioblastoma cancer cells derived from Iraqi patients. The infected cells' morphology was studied to measure the cytolytic effect of the NDV in cancer cells. Results showed that After 24 to 72 hours of inoculation, all of the chicken embryos died when the AMHA1 Iraqi NDV strain was injected. Cell viability assay showed that the NDV-AMHA1 strain has cytotoxicity at MOI of 0.1, 0.5, and 1 for 72 hours of exposure to cancer cells. The morphological analysis showed that NDV induces cell death in the infected cells with both necrotic and apoptotic features. In conclusion, the study focuses on the propagation of the oncolytic NDV as a biological agent capable of overcoming treatment resistance through infecting and replicating inside cancer.
Nanotechnology
Anwar Sabri Jawad; Qasim N. Thewaini; Sharafaldin Al-Musawi
Abstract
Aluminum oxide, often known as Al2O3, is a chemical compound of aluminum and oxygen with the formula Al2O3. It's the most common of many aluminum oxides, known as aluminum (III) oxide. The study investigates the cytotoxicity and antibacterial effects of Aluminum oxide nanoparticles (Al2O3-NPs) in different ...
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Aluminum oxide, often known as Al2O3, is a chemical compound of aluminum and oxygen with the formula Al2O3. It's the most common of many aluminum oxides, known as aluminum (III) oxide. The study investigates the cytotoxicity and antibacterial effects of Aluminum oxide nanoparticles (Al2O3-NPs) in different cells and bacteria. Different characterization methods such as dynamic light scattering (DLS), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) have been used to evaluate morphologies and physicochemical properties of Al2O3-NPs. MTT technique is used for determining NPs cytotoxicity. The size distribution of Al2O3-NPs was 68 ± 12 nm in diameter, while the zeta potential was (-36 ± 10 mV). There is no toxicity by using the MTT assay, as well as showed antibacterial activity was formed at 200 µg/mL, while the higher antibacterial activity was occurring at (18 ± 0.2) and (17 ± 0.1) for Proteus Vulgaris and Streptococcus pyogenes, respectively. The findings confirmed that the Al2O3-NPs have small dimensions, high stability, and increased antibacterial activity.
